• Acetaminophen is a pain reliever and a fever reducer.
• Diphenhydramine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in the body. Diphenhydramine prevents sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.
• Acetaminophen and diphenhydramine is used to treat watering of the eyes, congestion, sneezing, and itchy throat caused by allergies and hay fever.
• Acetaminophen and diphenhydramine may also be used for purposes other than those listed in this medication guide.

What happens if I miss a dose?

• Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

• Seek emergency medical attention.
• Symptoms of an acetaminophen and diphenhydramine overdose may include nausea, vomiting, diarrhea, abdominal pain, sweating, seizures, confusion, sedation, insomnia, tremor, hallucinations, and an irregular heartbeat.

What should I avoid while taking acetaminophen and diphenhydramine?

• Use caution when driving, operating machinery, or performing other hazardous activities. Acetaminophen and diphenhydramine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
• Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking acetaminophen and diphenhydramine. Also, alcohol is very damaging to your liver when it is taken with acetaminophen.
• Acetaminophen and diphenhydramine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if acetaminophen and diphenhydramine is taken with any of these medications.

What are the possible side effects of acetaminophen and diphenhydramine?

• If you experience any of the following serious side effects, stop taking acetaminophen and diphenhydramine and seek emergency medical attention:
· an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
· liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, or severe fatigue);
· blood problems (easy or unusual bleeding or bruising); or
· low blood sugar (fatigue, increased hunger or thirst, dizziness, or fainting).
• Other, less serious side effects may be more likely to occur including:
· dry eyes, nose, and mouth;
· drowsiness or dizziness;
· blurred vision;
· difficulty urinating; or
· excitation in children.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.